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Overview: The “fight or flight” response to stress has been a part of our DNA since prehistoric times, and these days it feels like anxiety is everywhere. Whether it’s making sure the bills are paid, obsessing over growing political divisions, or confronting a global pandemic, there seems to be no shortage of things to worry about. Though humans seem to be more stressed than ever, it also has never been more important to learn how to cope with stress. This special issue of Health magazine looks at the evolutionary and biological roots of stress, the latest developments in research into understanding and alleviating its causes, tips for reducing and managing it in your everyday life, and even how it can be put to good use. Learn how to cope with the never-ending news cycle, the perils of social media, and the pressure of work-life balance while managing stress at every age.